Objective: To analysis the economic vulnerability of village clinic in Shandong province. Methods: Evaluation index were selected then methods of set pair analysis and obstacle factors analysis were adopted to do this analysis. Results: From 2012-2014, the economic sensibility and resiliency of village clinic were high, the index of economic sensibility and resiliency were higher than 0.87 and 0.96 respective. In general, the economic vulnerability of village clinic was acceptable, the economic vulnerability index was lower than 0.26. Income from diagnosis and treatment was the main contributing factor for economic sensibility. The obstacle index from 2012-2014 were 0.0468, 0.0426 and 0.389. Limit of the new rural cooperative medical system was the main obstacle factor for economic resiliency. The obstacle index from 2012-2014 were 0.5378, 0.4558 and 0.4942. Conclusion：The economic vulnerability of village clinic is acceptable, but in risk which means “high sensibility- high resiliency- low vulnerability”. People’s choice of health care service and operating costs of village clinic were main reasons of economic vulnerability. Limit of the new rural cooperative medical system is the key obstacle factor of economic resiliency.