Objective: Through in-depth analysis and study on the Japan price management mechanism and making comparative analysis, to provide a reference for drug price management policy in China . Methods: Through literature research and descriptive analysis, clarify specific Japan drug price management mechanism and make comparative analysis with China in the field of current macro environment, management systems and pricing method etc , and provide tailored suggestions for drug price management in China . Results and conclusion: Japan canceled drug make up system, To a large extent thanks to Japan healthcare functions of centralized management, thanks to drug price management system with science and multiparties reached consensus , established a set of mechanism of market formed price, especially in innovation drug pricing, international reference price , generic drug consistency evaluation, and generic drug pricing etc , with more scien tific and evidence based process, essentially is implementation of reimbursement payment price management, which provide reference meaning in the future for developing reimbursement payment price and establish ing scientific price management mechanism. in China.