Objective: To study the interaction between health human capital investment and urbanization in China . Methods: Through the establishment of a comprehensive evaluation index system of health human capital investment and urbanization, using the coupling model of physics, this paper carries out an empirical analysis on the coupling of health human capital investment and urbanization from 1995-2015. Results: The investment of health human capital and the level of urbanization showed a slow upward trend, but the development level of them was not high; The two systems show the trend of co evolution, but still show low coupling strength and low coordination level; The coupling strength between the two increases first and then remains stable, and the coordination increases gradually; Health human capital investment system, health expenditure of the greatest contribution, city system, city population contribution. Conclusion: Increase investment in health human capital, while focusing on health human capital investment, to better play the role of health expenditure on the promotion of Urbanization; Increase food expenditure, to ensure the basic role of food expenditure on the development of Urbanization