Abstract Objective: To analyze the health service utilization and medical expenses of outpatient with chronic kidney disease in Wuhan, to understand the security effect in patients with chronic kidney disease in the basic medical insurance system, put forward suggestions to strengthen comprehensive management of chronic kidney disease. Methods: Questionnaires were used to investigate 267 CKD outpatients of 6 first-class hospitals in Wuhan. Expert consultation method was used to interview the kidney doctors. Descriptive analysis method was used to analyze the utilization of health services, disease economic risk, catastrophic expenditure phenomenon, medicare satisfaction, understand the health care effect of CKD outpatients with basic medical insurance. Results: CKD patients have more frequent use of outpatient services, average outpatient expenditures of UEBMI outpatients were higher than the others, drug expenditures of NCMS patients were significantly higher than the others. Conclusion: More attention need to be paid for rural residents, to strengthen prevention education and early management and improve the management of chronic kidney disease outpatient insurance policy.