Objective To observe and analyze the effects of information intelligence technology in hospital operation decision. Methods Relevant factors have been analyzed vertically before and after the application of information intelligence technology in Beijing Cancer Hospital. In this case, data should be analyzed before and after the usage of the information intelligence technology, in terms of medical quality (bed usage, average length of hospitalization, the number of cases, etc.), workloads (number of visits, number of discharged patients, etc.), social benefits (patient satisfaction and employee satisfaction), and economic benefits (total assets, net assets, fixed assets, business income, per capita business income, etc.). At the same time, version SPSS20.0 could be used in the statistical data analysis. Results After the implementation of information intelligence technology, bed occupancy rate and the number of discharged was higher than that before implementation, as well as average length of hospitalization was significantly lower than before. Secondly, the number of visits and discharged persons was much higher than those before implementation. Thirdly, total assets, net assets, business income and per capita business income were more than before implementation. Last but not least, the satisfaction rate of patients and staff after the implementation of the information intelligence technology was significantly higher than those before, and the comparison of differences had statistical significant meaning (P <0.05). Conclusion Information intelligence technology could improve medical process and service efficiency, as well as reduce medical disputes and doctor - patient contradiction in hospital operation decision–making. Moreover, the satisfaction of doctors and patients could be ameliorated, manpower and material resources could be saved significantly as well, and the management efficiency would be effectively improved