Objective: to ensure the safety of hospital funds under multiple payment modes in the innovative use of multiple payment modes, the improvement of hospital outpatient procedures and the management of financial internal control. Methods: through the research related to use and operation of other units, and repeated communication between hospital departments, comprehensive carding pay model process of internal control management, the use of information network technology to strengthen the design of process control. Results: under the multi-payment mode, the hospital fund security is controlled under the continuous optimization information process. Conclusion: the application of multiple payment modes puts forward new requirements for the internal control management of hospitals, and ensures the safety of hospital funds through continuous improvement of internal control management