It sorts out the cost composition of the current hospital,current situation, problems and objectives of cost control. The essence of cost control, the mechanism analysis of human resources and value creation, and the role of human resources in value cost control of public hospitals are analyzed. Based on the construction of human resource value creation centered value, control and implementation system, public hospitals transform the concept of cost control to shape the hospital resource ecosystem, empower human resource value creation and improve the effect of cost control. In the process of implementing business-focused, closed-loop system and clinically active cost control in public hospitals, the development of specialized disease diagnosis and treatment business determines the effect of management and control