Objective: To compare the direct medical cost between domestic and imported laparoscopic staplers for patients with colorectal cancer undergoing laparoscopic surgery in the real-world setting. Methods: A total of 1187 patients with colorectal cancer discharged from the Department of Gastrointestinal Surgery of a tertiary hospital from January 2019 to July 2021 were selected. It used a generalized linear model to compare the costs between domestic and imported staplers. Subgroup analysis were applied based on the amount of nails used in the sample. Results: Compared with imported staplers, domestic staplers saved 5199.78 yuan, 7359.02 yuan and 7597.32 yuan in stapler fees, intraoperative disposable medical consumables fees and medical consumables fees, respectively. The results of the subgroup analysis showed that the use of a domestic lumpectomy clutch was more economical in the group with ＞2 staples compared to the group with ⩽2 staples. Conclusion: The domestic staplers are more economical for patients with colorectal cancer undergoing laparoscopic surgery.