Objective: To explore the setting of quotation incentives for public hospitals，in order to optimize and improve the pricing model of complex medical service items，and to provides for the formation of a new price mechanism. Methods: Using probability theory and mathematical statistics to solve and analyze the constructed medical insurance fund expenditure model. Results: For any public hospitals participating in the quotation，there is a unique and optimal reward coefficient corresponding to it，and the expected expenditure of the medical insurance fund of the government price regulation department is minimized. In addition，the optimal reward coefficient increases gradually with the increase of the number of public hospitals participating in the quotation. Conclusion: The optimized pricing model for complex medical service items not only takes into account the interests of hospitals，patients and medical insurance，but also can effectively prevent public hospitals from inflating prices，which has good application value.