Objective: To analyze the current situation of price management of medical service in The Yangtze River Delta Region，and to provide basis for reasonable pricing and adjustment in the Yangtze River Delta Region. Methods: The latest medical service project specifications and price summary tables issued by Shanghai，Jiangsu Province，Zhejiang Province，Anhui Province were collected to establish and sample the database，and conduct the quantitative and qualitative analysis based on EXCEL 2016 Software. Results: There are significant differences in the overall price level of medical service in the Yangtze River Delta Region (P＜0.05). There are differences in price level and dispersion degree among different types of medical services. The price of Traditional Chinese medicine treatment and comprehensive service is lower than that of diagnosis and treatment. Medical service price level is positively correlated with economic development level (R2=0.49). The prices of all kinds of medical services in Shanghai are the highest except for traditional Chinese medicine treatment. The prices of medical services in Jiangsu province are generally low compared with the level of economic development. Conclusion: There are great differences of medical service price in the Yangtze River Delta Region，and the overall price comparison relationship tends to be reasonable. It is suggested to unify the price standard of medical services，make the pricing of TCM medical services more scientific，raise the price of medical services reflecting the value of technology and labor，and optimize and adjust the price according to the level of economic development.