Objective: Public hospitals belong to state-owned economic organisations，and the formation of a combined internal audit and state audit force for public hospitals is conducive to strengthening audit supervision power. Methods: Using the game model method，it explores the effective supervision scheme of internal audit and national audit for the public hospitals. Results: The probability of effective management of public hospitals can be raised by increasing the supervision probability of national audit institutions and strengthening rewards to national audit institutions and punishments to internal audit institutions. Conclusion: Increasing the audit strength of national audit institutions and optimizing the reward and punishment system of audit can promote the effective management of public hospitals.