Objective: To analyze the changes of drug expenses of inpatients with cerebral ischemic diseases with major comorbidities and concomitant diseases in 6 hospitals of the first Diagnosis Related Group(DRG) pilot in Beijing during the comprehensive reform of separation of medicines and medical consumption linkage in Beijing，and provide references for deepening these two rounds of reform. Methods: The interrupted time series model was applied to analyze the changes of the average drug expenses and the proportion of drug expenses before and after these two reforms in 6 DRG pilot hospitals from 2016 to 2020 . Results: The overall level of average drug expenses，western drug expenses and Chinese drug expenses decreased significantly，and expenses continued to decrease after the reform. The proportion of total drug expenses，western drug expenses and Chinese drug expenses also decreased significantly，among which the proportion of total drug expenses and western drug expenses continued to decrease after the reform，and the proportion of Chinese drug expenses remained stable. Conclusion: These two rounds of reform have basically achieved the expected policy goals. but attention should be paid to the long-term cost control effect and the balanced development of Chinese and western medicine. It suggested to perform the DRG important guiding function，promote the linkage reform of the centralized purchase of drugs with volume with DRG，establish DRG performance evaluation system，promote the organic combination of DRG payment and clinical pathway，and explore payment according to TCM diseases.