Objective: To analyze the cost-effectiveness of the active screening strategy for close contacts，and provide scientific basis for the early detection and prevention of tuberculosis. Methods: The decision tree Markov model of close contact screening strategy was established to compare the cost-effectiveness of passive screening strategy and active screening strategy. Results: Compared with the passive screening strategy，the incidence of latent infection，incidence rate of tuberculosis，and mortality of the active screening strategy once a year，the discontinuous active screening strategy twice a lifetime and the active screening strategy once a year all decreased in turn. The cost of each additional 1QALY was 8973.3 yuan8995 yuan，and 10801.2 yuan，lower than the WTP threshold standard. These three active screening strategies all had cost utility advantages. Conclusion: As an economic and effective public health intervention measure，continuous active screening for close contacts has high cost-effectiveness value.