Objective: Through the scientific design of the threshold boundary of medical insurance fund regulatory indicators and its measurement strategy under the DRG payment, the possible problems in medical institutions and medical insurance operations can help realize the intelligent monitoring of medical insurance funds throughout the process and cycle, and improve the efficacy of medical insurance funds. Methods: According to the design concept of scientific setting, precise identification, and classification and stratification, the threshold boundary type and calculation method of the indicators are determinedbased on the simulation results of the operation data of some DRG pilot cities across the country. Results: The threshold boundaries of regulatory indicators are divided into upper, lower and upper and lower boundaries according to the connotation and orientation, and the design ideas of regulatory indicator thresholds for health insurance funds under the DRG payment model are constructed based on policy needs, expert judgment and statistical principles.Conclusion: The policy threshold should be synchronized with the reform goals and dynamically adjusted, and the statistical threshold calculation method should be continuously improved to improve the accuracy and efficiency of identification. Threshold risk identification technology should be embedded in the intelligent supervision platform, and manual review should be strengthened.