Objective: To analyze the characteristics, losses, and reasons for accidental falls in inpatients of rehabilitation hospi- tals, propose preventive measures, and to provide scientific references for hospital operations management. Methods: A retrospective study was conducted to analyze the general information, diagnosis and treatment, falling characteristics, and economic losses of 17 529 inpatients in a rehabilitation hospital from 2019 to 2022. Results: The incidence of accidental falls among inpatients in this study was 0.95%, accounting for 48.13% of hospital adverse events. There was no statistically significant difference in the incidence of falls among patients of different genders and ages (P＞0.05). The hospitalization days and total hospitalization expenses of the fall group were significantly higher than those of the non-fall group (P＜0.05), with an average increase of 25 days and 6 400 yuan in to- tal hospitalization expenses. There was a statistically significant difference in the incidence of falls among patients with different dis- eases (P＜0.05). Among them, patients with spinal cord injuries, burns, and musculoskeletal injuries had significantly longer hospital- ization days (31-60 days) and economic losses of 68 800 yuan, 52 900 yuan, and 35 000 yuan, respectively. Conclusion: Accidental falls are the main adverse events in rehabilitation hospitals. Patients with severe injuries such as spinal cord injuries and burns are more prone to falls. The economic losses caused by falls in rehabilitation hospitals are significantly higher than those in comprehen- sive hospitals. Rehabilitation hospitals should develop targeted interventions based on patient characteristics to prevent falls and re- duce economic losses.