Objective: To evaluate the current status of quality of life among patients with thyroid nodules/tumors and analyze itsinfluencing factors, in order to provide reference suggestions for improving the life quality of these patients.Methods: An online sur-vey was conducted using the EQ-5D-5L scale to investigate patients with thyroid nodules/tumors who met the inclusion and exclusioncriteria.One-way ANOVA and multi-level linear regression analysis were used to analyze the influencing factors.Results: The meanhealth utility value of patients with thyroid nodules/tumors was 0.708±0.298, and the mean EQ-VAS score was 65.45±27.82.Gender,age, household registration type, marital status, average annual household income, neck exposure history, family history of thyroid can-cer, and the nature of nodules/tumors had a statistically significant impact on the health utility value and EQ-VAS scale of patientswith thyroid nodules/tumors(P＜0.05).Conclusion: The quality of life of patients with thyroid nodules/tumors is poor.Various factorsaffecting the quality of life should be considered comprehensively to enhance the physiological function and psychological resilience ofpatients, and to improve their quality of life.