In order to explore the big data audit work of public hospital under high quality development, it takes the practical ex- ploration of the First Affiliated Hospital of the University of Science and Technology of China as an example, proposes the design con- cept, overall architecture, main functional modules, and data security management of digital audit platform. The results show that the application of the platform can realize the integration and information sharing of multi-domain business data, realize continuous online audit, intensively and efficiently use audit resources, and solidify digital audit results, thus providing some working ideas and experi- ence references for innovative audit mode in public hospitals.