Objective: To construct a multi-dimensional decision-making framework for the selection of drugs in the medical insurance catalogue based on the Evidence and Value: Impact on Decision Making (EVIDEM), so as to solve the problem of multi-stakeholder and multi-dimensional value in the adjustment of the medical insurance drug catalog. Methods: According to the steps of Multi-criteria decision analysis (MCDA), a multi-dimensional decision-making framework for drug adjustment in the medical insurance catalogue was preliminarily constructed. Experts in medical insurance, medicine, medical treatment and other related work fields are invited to form indicators and their weights by two rounds of Delphi method. Results: An index structure of 14 criteria was formed, including disease, clinical, economic, innovation, fairness and evidence, and 14 criteria, including disease severity, disease affected population, efficacy and safety. Conclusion: The multi-dimensional decision-making index framework established by EVIDEM has strong practical value and can provide technical support for the adjustment decision of medical insurance catalogue drugs.