Objective: To explore the implementation effect and problems of the policy of encouraging generic drug list in China, in order to further improve the policy of generic drug list. Methods: The selection principle of encouraging generic drug list in China, the characteristics and implementation status of included drugs, and the existing problems are analyzed. Results: The therapeutic fields of drugs included in the two batches of catalogs are relatively concentrated in the nervous system, respiratory system, tumor, en- docrine and metabolic diseases and infectious diseases. Among the 50 drugs, there are 24 new applications for generic drugs, 2 drugs are included in the priority review, 19are approved for listing, and 20 are included in the medical insurance catalog. At present, there are still problems in the development of the two batches of catalogs, such as the ineffective implementation of the second batch of cata- log policies, the phenomenon of“polarization”in the research and development of some generic drugs, the lack of priority review sys- tem, and the coordination and linkage between departments to be strengthened. Conclusion: It is necessary to improve the system de- sign, strengthen the selection management of reference preparations, improve the supporting incentive measures, mobilize the enthusi- asm of enterprises in research and development, dynamically adjust the generic drug catalog, and strengthen the coordination and link- age of departments.