Overall budget management is an important means to achieve the strategic goal of high-quality development of hospitals. Taking the First Affiliated Hospital of Guangzhou Medical University as an example, there are some problems in the current overall budget management, such as disconnection between budget preparation and implementation, imperfect organizational structure of budget management, unreasonable time nodes of budget preparation and reporting, and imperfect project library of budget preparation. The hospital explores the overall budget of public hospitals by comprehensively adjusting the content of budget preparation, optimizing the organization of budget management, modifying the time nodes of budget preparation and reporting, improving the project library of budget preparation, and implementing budget execution control, in order to provide references for the overall budget management of public hospitals.